This study examined the relationship between work-life balance and job satisfaction among commercial bank employees in Oyo State, Nigeria. It specifically assessed how work interference with personal life (WIPL), personal life interference with work (PLIW), and workpersonal life enhancement relate to employees' job satisfaction. The study adopted a correlational cross-sectional survey research design. The population comprised employees of selected commercial banks operating in Oyo State, from which a sample of 203 respondents was drawn using a multi-stage sampling approach involving purposive and random sampling techniques. Primary data were collected through a structured questionnaire adapted from prior studies. Descriptive statistics, including means and standard deviations, as well as inferential statistics comprising Pearson correlation and multiple regression analysis, were employed for data analysis. The results indicated that work interference with personal life (r = -0.184, p < 0.05) and personal life interference with work (r = -0.201, p < 0.05) were negatively associated with job satisfaction, while work-personal life enhancement (r = 0.547, p < 0.05) showed a strong positive relationship. The regression results revealed that the dimensions of work-life balance jointly explained 33.1% of the variance in job satisfaction (R² = 0.331, F = 32.844, p < 0.001), with work-personal life enhancement (β = 0.529, p < 0.05) emerging as the only significant predictor. The study concludes that positive interaction between work and personal life is a critical determinant of job satisfaction among bank employees. It recommends that bank management implement flexible work arrangements and supportive organisational practices that promote work-personal life enhancement.